Colorectal cancer

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What Is Colorectal Cancer?

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Colorectal cancer is a type of cancer that starts in the colon (large intestine) or rectum. It typically begins as a polyp (a small growth on the inner lining), which can become cancerous over time if not removed.

Types of Colorectal Cancer

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Adenocarcinoma (most common – 95%)

Starts in mucus-producing glands in the colon/rectum.

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Carcinoid Tumors

Begin in hormone-producing cells.

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Gastrointestinal Stromal Tumors (GISTs)

Rare tumors starting in connective tissue.

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Lymphomas

Cancers of immune system cells that may start in the colon.

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Sarcomas

Begin in blood vessels, muscle, or connective tissue.

Symptoms of Colorectal Cancer

Symptoms often appear in later stages and may include:

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Changes in bowel habits (diarrhea, constipation)
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Blood in stool or rectal bleeding
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Abdominal cramps or discomfort
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Unexplained weight loss
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Weakness or fatigue
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Incomplete bowel emptying feeling

If symptoms persist for more than 2–3 weeks, consult a doctor.

Risk Factors of Colorectal Cancer

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Causes of Colorectal Cancer

While the exact cause is not always known, it is generally linked to:

Genetic mutations (inherited or acquired)
Lifestyle factors (diet, physical inactivity)
Chronic inflammation in the colon or rectum

How to Prevent Colorectal Cancer

While not all cases are preventable, risk can be reduced by:

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Routine screenings (colonoscopy after age 45 or earlier if high-risk)
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Healthy diet (rich in fiber, fruits, and vegetables)
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Limit red and processed meat
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Regular physical activity
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Maintain healthy weight
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Avoid tobacco and alcohol
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Aspirin use (in high-risk individuals, under doctor’s advice)

Treatment of Colorectal Cancer

Treatment depends on the stage, location, and overall health of the patient:

Surgery

To remove tumors or affected parts of the colon/rectum.

Chemotherapy

To destroy cancer cells, often after surgery.

Radiation Therapy

Mainly used for rectal cancer.

Targeted Therapy

Drugs that block specific cancer growth signals.

Immunotherapy

Boosts the body’s immune system to fight cancer (for advanced cases).

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Procedures for Colorectal Cancer

Chemotherapy can be delivered through:

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Colonoscopy with Polypectomy - For early polyps or tumors
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Colectomy – Removal of part or all of the colon.
  • Partial Colectomy
  • Total Colectomy
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Removal of the rectum (for rectal cancer).
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Temporary or permanent diversion of the bowel.
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Less scarring, faster recovery.

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Chemo/radiation before surgery to shrink tumor.

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Chemo/radiation after surgery to reduce recurrence.