Chemotherapy

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What is Chemotherapy?

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Chemotherapy is a type of cancer treatment that uses powerful drugs to destroy or slow the growth of rapidly dividing cancer cells. It can be used alone or alongside surgery, radiation, or immunotherapy.

Types of Chemotherapy

Chemotherapy is classified based on how it's used and what kind of drugs are involved

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Curative Chemotherapy – Aims to cure cancer completely.

Adjuvant Chemotherapy – Given after surgery to destroy any remaining cancer cells.

Neoadjuvant Chemotherapy – Given before surgery to shrink tumors.

Palliative Chemotherapy – Used to relieve symptoms and improve quality of life, not necessarily to cure.

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Alkylating Agents – E.g., Cyclophosphamide

Antimetabolites – E.g., Methotrexate, 5-FU

Anti-tumor Antibiotics – E.g., Doxorubicin

Plant Alkaloids – E.g., Vincristine, Paclitaxel

Topoisomerase Inhibitors – E.g., Irinotecan

Mitotic Inhibitors – E.g., Docetaxel

Symptoms / Side Effects of Chemotherapy

Since chemo affects fast-growing healthy cells too (like those in hair, digestive tract, and bone marrow), it can cause:

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Fatigue
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Nausea and vomiting
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Hair loss
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Mouth Sores
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Loss of appetite
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Diarrhea or constipation
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Low blood counts (anemia, infections)
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Fertility issues
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Memory/concentration changes (“chemo brain”)
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Emotional distress

Risk Factors of Chemotherapy

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Causes for Receiving Chemotherapy

Presence of cancer diagnosed through biopsy and imaging
Cancer is spreading or aggressive
To shrink tumors before surgery
Cancer has returned (recurrence)
Cancer is not suitable for surgery or radiation alone

How to Prepare for Chemotherapy

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Blood tests to assess liver/kidney function
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Dental check-up (to avoid infections)
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Discuss fertility preservation if needed
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Central line or port placement (for IV drugs)
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Plan for managing side effects (anti-nausea meds, wigs, support)

Treatment with Chemotherapy

Administered in cycles

(e.g., every 2–3 weeks) to give your body time to recover

Combination therapy (multiple chemo drugs together)

Targeted therapies or immunotherapies may be combined with chemo

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Procedures of Chemotherapy

Chemotherapy can be delivered through:

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Most common, via veins or port

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Taken at home

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Subcutaneous or intramuscular

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Directly into the abdomen

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Into cerebrospinal fluid for brain cancers

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As a cream (for certain skin cancers)